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In the event of a fire that is too large to be managed with a portable extinguisher, the first step of isolating it is crucial to prevent the fire from spreading further and to protect people and property. Isolating the fire can involve closing doors or shutting off ventilation systems to limit the oxygen supply and contain it to a specific area. This action buys time for emergency responders to arrive and take over the situation with appropriate resources.

After isolating the fire, activating alarms and calling for backup are important subsequent steps. However, they follow the immediate action of isolating the fire to ensure safety. Spraying water is typically not advised for large fires until trained personnel can assess the best approach, as it could exacerbate the situation depending on the materials involved. Thus, prioritizing isolation is a proactive measure that focuses on safety and damage control.